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The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a oldetowntimes.net/sims-4-debug-cheat-codes-get-the-most-out-of-your-game heterodimer with the retinoid X receptor (RXR). Calcitriol signalling regulates various biological functions, including calcium and metabolism of phosphorous as well as parathormones cell proliferation, and the regulation of adaptive and innate immunity.

A T > C base alteration in the promoter region of the VDR variant rs11568820 removes the binding site for transcription factor Cdx2 located upstream of exon 1e. This leads to the production of a less sized protein with decreased transcriptional activity. The F allele of this variant can be found at a high frequency in Asians and Europeans and at a lower frequency in Sub-Saharan Africa.

The findings of this study have improved our understanding of the role that VDR gene polymorphisms might play in modulating the response to dietary supplementation with calcitriol. People who carry the TaqI and FF genotypes of the FokI polymorphisms show higher transcriptional activation, and are associated with higher calcium absorption, higher bone mineral density, and a lower risk of fractures. Further research using an overall design is needed to improve our understanding of how these genetic variations affect vitamin D supplementation and its clinical significance.